Scientific Program

Conference Series Ltd invites all the participants across the globe to attend 8th World Conference on Women’s Health and Breast Cancer Abu Dhabi, UAE.

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Scientific Program Day 1
Scientific Program Day 2

Day 2 :

Keynote Forum

Zoella Vlamaki

NHS Trust, UK

Keynote: Past present and future of medicinal practice and breast cancer prevention

Time : 09:00- 09:45

Conference Series Womens Health Meet 2018 International Conference Keynote Speaker Zoella Vlamaki photo
Biography:

Trained In General Surgery, Laparoscopic Surgery, Endocrine Surgery and Breast Surgery, starting her work studies and training, in Athens Greece, Hippokration General Hospital. She developed her interest in diagnosis and treatment of breast diseases and breast cancer, advancing breast surgical Oncoplastic skills and breast reconstruction when she moved on to UK in 2001, working in NHS England. She has a broad international experience working in different continents of the glob. With her passion following Hippocratic principles, her interest spread to Integrative medicine in prognostic and preventive medicine and wellbeing. She became, American board Certified in Wellbeing and Anti aging doctor. Her Practice and the Biovitality clinic integrates breast cancer diagnosis and treatments. Biovitality Clinic aims for everyone body and mind health. She continues to work as a Consultant Breast Surgeon. The Biovitality clinic has the passion to know you, create your individual path of wellbeing, beauty of body and mind for a bright future.
 

Abstract:

Keynote Forum

Taghreed Al Nusairat

King Hussein Cancer Foundation, Jordan

Keynote: Study of knowledge, attitudes and practices (kap) of jordanian women aged 25-65 years towards early detection and screening of breast cancer

Time : 10:50-11:35

Conference Series Womens Health Meet 2018 International Conference Keynote Speaker Taghreed Al Nusairat photo
Biography:

Taghreed Al Nusairat, holds a Master of public health from the University of Jordan, with a Bachelor degree of nursing, is the Head of service delivery and quality management department and monitoring and evaluation department, within the Jordan Breast Cancer Program (JBCP) in the King Hussein Cancer Foundation. She is the chief principle for any research and studies held within the program with over 16 years’ of experience in the health field and applying a strong expertise in quality management and breast cancer screening services provision, long-term strategic planning. Previous to this, Taghreed held various positions as outreach program specialist, nursing supervisor and coordinator for the bone marrow and stem cell transplantation, head nurse within the Hematology and Chemotherapy Unit in KHCC.
 
 

Abstract:

Statement of the Problem: The cancer registry in Jordan derived that cancer is the second leading cause of death accounting 16.5% of deaths. Particularly in 2014, it was noted that 20.8% of new cancers are breast cancer. The majority of breast cancers cases are amendable to early detection, via periodic screening. Spreading awareness concerning breast cancer and periodic screening among the population has a positive impact on decreasing mortality. The study is aimed to explore the knowledge, attitude and practices of the female population of Jordan ages from 25 to 65 years towards early detection and screening of breast cancer. Methodology & Theoretical Orientation: A qualitative and quantitative interview was conducted with individuals ages between 25 and 65 years old (n=1502) that were randomly selected. The data collected was analyzed using SPSS software, and tested for significance using t-test. Findings: Results have shown that 85% of the participants are aware of breast cancer. The source of their awareness was mainly through TV (72%) and the majority (73%) were not actively looking to increase their knowledge. Only 19% of participants underwent clinical breast examination within the past year while only13% is familiar with mammogram and were subject to it. As for the visit to early detection clinics, 56 % of the Jordanians are willing to visit the clinic if they have doubt about breast cancer, while physician’s recommendation for detection and screening was 9% and lower. Finally, only 30% of participants believe that breast cancer can be detected in early stages. Conclusion & Significance: The lack of awareness raises concerns since it leads to low practices of early detection and screening thus leading to an increase in morbidity and costs of treatment. Further initiatives should be taken to increase awareness on early detection and screening for breast cancer in the Jordanian community. 

Keynote Forum

Omar Tillo

Bedford Hospital NHS Trust, United Kingdom

Keynote: Breast reconstruction: How to establish a new service

Time : 11:35-12:20

Conference Series Womens Health Meet 2018 International Conference Keynote Speaker Omar Tillo photo
Biography:

Omar Tillo is a Plastic and Reconstructive Surgeon who’s special interest is breast and body reconstructive and aesthetic surgery. After graduating in 1997 he completed specialty training in General Surgery. He later completed a second specialty training in plastic and reconstructive surgery in some of the leading United Kingdom NHS Hospitals. He developed early special interest in Breast and Body Surgery and build a successful NHS and private practice. During his employment in Bedford Hospital NHS Trust he succeeded in establishing a comprehensive breast reconstruction service providing all range of procedures to the local residents from implant based to autologous free flaps. His team was recently nominated for the ‘Team of the Year’ award.
 

Abstract:

Breast cancer is the most commonly diagnosed cancer in females affecting 1 in every 8 women in their lifetime. In the majority of cases, surgical excision continues to be the first line of treatment by means of mastectomy or wide local excision. These surgical modalities very often result in breast or chest deformities that can have devastating psychosocial impact on patients, such as low self esteem and feeling incomplete, with adverse impact on their quality of life in terms of sexual activity, relationships, clothing, sport, swimming and other daily activities. Unfortunately, the large majority of women having breast surgery worldwide are not offered even the simplest types of reconstruction due to lack of awareness, training or resources. Even in the developed countries it is estimated that 25-50% of women are still not offered the full range of reconstruction options. This paper provides a step-by-step guide in establishing a new breast reconstruction service starting with setting up a dedicated local staff teaching program, arranging specific logistics and equipment, fulfilling administrative and legislative processes, implementing quality assurance measures, audits and patient reported outcome measures. This is derived from the author’s experience in establishing a breast reconstruction service in an NHS General Hospital in the United Kingdom. A review the current and National Guidelines for best practice is also reviewed along with sources of patient’s education material. In conclusion, no woman should be denied the right of having breast restoration surgery following the treatment of cancer. This service should be made available universally across the globe. Internet and social media platforms are powerful and cost effective educational tools for patients.

  • Breast Cancer | Women’s Health and Fitness | Breast Cancer: Challenges, Breakthroughs
Speaker

Chair

Chinar A Dzayee

Rizgari teaching hospital, Iraq

Session Introduction

Heba Alshaeri

Fakeeh College for Medical Sciences, Saudi Arabia12

Title: Antiproliferative activity of Annona muricata extract on triple negative breast cancer cells
Speaker
Biography:

Heba K Alshaeri has pursued PharmD degree at King Abdulaziz University, Saudi Arabia and an MPH degree at Loma Linda University, USA in 2013. In 2013 she joined MCPHS University for Doctoral program in Pharmacology and she has completed her PhD degree in 2018. She is a Member of the American Society for Pharmacology and Experimental Therapeutics and the American Association of Pharmaceutical Scientists.
 

Abstract:

Statement of the Problem: Triple Negative Breast Cancer (TNBC) cells are a subtype of breast cancer that lack of Estrogen Receptors (ERs), Progesterone Receptors (PRs) and Human Epidermal Growth Factor Receptor 2 (HER2). This type of breast cancer has poor prognosis and accounts for 15-20% of newly diagnosed Breast Cancer (BC) cases. Annona muricata is a tropical plant and has been used as a folk medicine to treat several diseases such as malaria, inflammation, diabetes and recently it was known to have anticancer activity on various cancer types. However, the underlying molecular mechanisms remain to be explored. Research Question/Hypothesis: We hypothesize that Annona muricata Ethyl Acetate (AMEA) extract and the isolated compounds will reduce cell proliferation and produce cell death by the induction of apoptosis. Moreover, AMEA or its active ingredients will interfere with the function of EGFR signaling activity in the TNBC cell line. Methodology: The effect of AMEA and F4 on the cell viability of BT-20 breast cancer cell line was analyzed by MTS assay. We measured caspase-3/7 activity and cytochrome C release as a marker of apoptosis. Also, the protein expression of Bax and Bcl-2 was determined using western blot. To investigate further of AMEA and F4 anti-cancer effect we measured cyclin D1 and EGFR signaling and its downstream proteins AKT, MAPK and NF-κB p65 protein expression by western blot analysis. Results: The AMEA showed significant decrease on BT-20 cell viability. Furthermore, AMEA and F4 produced anti-proliferative effect via inhibiting the EGFR phosphorylation and the phosphorylation of its downstream signaling proteins including AKT and MAPK. These effects were accompanied with down-regulation of cyclin D1 production resulting in cell cycle arrest at G1/S phase. Moreover, this compound decreased significantly NF-κB p65 protein expression in the nuclear fraction, therefore, inhibiting its activation and preventing the induction of cell survival. Our data indicated that neither AMEA nor F4 had significant effect on apoptosis biomarkers when tested on Bcl-2, Bax, cytochrome C and caspase 3/7 activities. Conclusion: These findings provide a scientific basis for the molecular mechanism of action of Annona muricata extract and its active fraction F4 in the treatment of TNBC. It has been demonstrated the anti-proliferative effect via EGFR-mediated signaling pathways which includes AKT/MAPK/NF-κB pathways and cyclin D1 inhibition.
 

Gul Cankaya

NHS Marmara University Pendik Training Hospital, Turkey

Title: Quality of life monitoring for women with breast cancer
Biography:

Gul Cankaya is currently working as a Surgical Nurse at NHS Marmara University Pendik Training Hospital, in Turkey. She has worked mostly in pediatric critical care unit, cardiovascular surgery operating room and general surgery operating room. She has attended international certification for Breast Cancer Nursing program (MEHEM).
 

Abstract:

Quality of Life (QoL) surveys are important tasks in health management for oncological patients. Ability to perform daily activities, patient satisfaction and levels of functionality are essential for evaluating QoL in breast cancer survivors. Hot flashes on tamoxifen treatment have been reported to decrease general quality of life in women with breast cancer. Long-term, disease-free survivors of breast cancer have an excellent QOL, many years after their breast cancer diagnosis. According to the World Health Organization’s International Classification of Functioning, Disability and Health (ICF), function is defined as the interactions between an individual, their health condition and the social and personal context in which they live. Breast cancer patients experience physical symptoms and psychosocial distress that adversely affect their quality of life. Healthcare providers and patients think that QoL assessments acceptable in helping breast cancer patients to overcome areas of QoL that have been affected by the disease.
 

Chinar A Dzayee

Rizgari teaching hospital, Iraq

Title: Encysted papillary carcinoma
Speaker
Biography:

Chinar A Dzayee has completed her Bachelor’s degree in Medicine from the Salahaddin University and her Master’s degree in General Surgery in 2008 from Hawler Medical University. She is currently working as a General Surgeon in Rizgari Teaching Hospital and Breast Clinic in Erbil. Her interests are in breast disease and surgery, diagnosis, treatment of benign and malignant breast disease and performing surgery. 

Abstract:

A 52 years old lady was presented with right bloody nipple discharge for 4 years. Ultrasound -RT breast-duct dilatation with irregular mass 24×10 mm within the duct, mammography shoes multiple dilated linear branching density from retro areolar area to the lateral margin of RT breast with nipple retraction. Sonographic guide core biopsy was done. Microscopically finding, dilated ductal space one supported by fibrous tissue other showed prominent ductal proliferation with epitheliosismild atypical change in fibrotic stroma, patient underwent surgery by excision of entire duct from nipple to distal part about 9×6×3 cm axilla not touched, sent for histopathology. Microscopical Finding: Intraductal (intracystic) papillary carcinoma, no invasion is seen, all margins were clear, ER positive, PR positive and HER2 negative. She passed smooth post-operative period and received radiotherapy and now on Tamoxifen treatment. Encapsulated Papillary Carcinoma (EPC) of the breast is a rare malignancy accounting for 0.5-1% of all breast cancers, Caucasians are the most common sufferers of EPC (63%), followed by Hispanics (12-30%), Asian/Pacific Islanders (10-13%) and African-Americans (7-10.5%). EPC can be presented either as a palpable mass in an otherwise normal breast or as a swollen breast due to the presence of a huge cystic mass within it. In some cases, nipple retraction may be present with or without nipple bleeding, requiring further examination using imaging and biopsy. EPC may also be simple mammographic findings without any clinical evidence. Almost 50% of the EPCs arise in the retro-areolar region. These lesions are characterized by indolent behavior and extremely favorable prognosis. Encapsulated PC can be treated with adequate local therapy. Routine use of adjuvant therapy, particularly chemotherapy, is clearly not appropriate in view of the very low risk of subsequent events. However, hormonal therapy may be indicated in certain cases such as recurrent PC.

Ee Ling Serene Tang

Tan Tock Seng Hospital, Singapore

Title: Understanding the demographics and clinical outcome of patients with idiopathic granulomatous mastitis
Speaker
Biography:

Serene Tang is a Breast Surgeon with special interest in granulomatous mastitis and advanced breast cancer. She is particularly interested in breast research and surgical education

Abstract:

Statement of the Problem: Idiopathic Granulomatous Mastitis (GM) is a rare, benign, chronic breast condition which can cause repeated abscess or mass formation in bilateral breasts. This can severely affect the quality of life of women who are affected by it. The natural history of GM as well as its optimal management is not well understood. This study aims to study the demographics of patients with GM and evaluate the most effective treatment method. Methodology & Theoretical Orientation: A retrospective review of 18 patients diagnosed with GM between 2012 and 2018 in a single institution in Singapore was carried out. Patients’ notes and treatment records were reviewed. Findings: The median age of GM patients was 32.5 years old (24-58). 50% of them were Chinese, 27.8% were Malay and 11.1% were Burmese. 72.2% (13/18) of patients presented with a breast lump with 46.2% (6/13) of these patients presenting with a lump more than 5 cm. 22.2% (4/18) presented with a breast abscess. 94.4% (17/18) of patients were treated with steroids, 27.8% (5/18) underwent surgery and 22.2% (4/18) were given antibiotics in the course of their GM treatment. Patients experienced a median of two flares (1-8) on treatment. 47.1% (8 of 17 patients) achieved resolution on prednisolone and none in the antibiotics group. Only one patient in the surgery group achieved complete resolution, as she underwent bilateral mastectomy. One patient who was managed with watchful surveillance spontaneously underwent resolution. The odds of resolution were 3.56 times (p=0.30) more likely with prednisolone than surgery. None turned malignant. Conclusion & Significance: GM is a benign recurrent, relapsing breast inflammatory condition that affects young females. Prednisolone appears to be the most effective amongst all the current treatment options. A multi-center study to evaluate response to various treatment options would aid in understanding of the nature of the disease.
 

Najwa Alfarra

King Faisal Specialist Hospital and Research Centre, Saudi Arabia

Title: New dimension of physical therapy for the oncology female patients with sexual dysfunction
Speaker
Biography:

Najwa Alfarra is currently working as an Assistant Head at King Faisal Specialist Hospital and Research Centre since 2015. She has experience in working as a Women's Health Specialist, Al-Riyadh Governorate, Saudi Arabia. She has her expertise in evaluation and passion in improving women’s health sexual dysfunction as a Physical Therapist specialized in that field. She treats different types of urinary incontinence, chronic pelvic pain, design pre-post-natal exercise program and sexual dysfunction conditions by using different modalities of treatment. 

Abstract:

Medical research continues to extend the life of cancer patients beyond their initial diagnosis. One of the challenges for both cancer survivors and the health care professionals who care for them is to comprehensively address all the issues that impact their quality-of-life. Issues regarding mobility, return to work, cosmetics and self-care are readily identified and addressed. There are other activities of daily living that may be more hidden but should be included in a comprehensive rehabilitation program. Continence (urinary and fecal) and the ability to engage in sexual activity have been well documented to impact the quality-of-life scores for individuals with various types of cancer. The pelvic floor plays a role with both continence and sexual activity. To effectively address pelvic floor dysfunction, a thorough understanding of pelvic floor anatomy and physiology is essential. The women’s health physical therapist will incorporate this knowledge with an appreciation of the impact of surgery, chemotherapy and radiation can have on the function of the pelvic floor. The therapist will evaluate the patient to determine the source of dysfunction, provide scientifically supported education regarding positioning to decrease pain, instructed the patient with certain exercise program and assist alleviating the symptoms to achieve optimal sexual function and treat the patient's dysfunction and improve their sexual intimacy limitations. There were few studies performed in that field and they found the pelvic floor muscle exercise, significantly improved pain with intercourse, sexual function and general quality of life in women with history of breast cancer. This study will find the impact of physical therapy in the treatment of sexual dysfunction in the Saudi oncology female patients.